Endocrine Abstracts

The aim of our study is to detect parameters which may predict recurrences during long-term follow-up in papillary thyroid cancer patients who achieved remission after primary treatment. The data of 492 patients who achieved selected remission criteria after primary treatment were recorded. Remission criteria were for anti-thyroglobulin (antiTg)-negative patients: no uptake in first iodine-131 whole body scan (WBS) after primary treatment and stimulated thyroglobulin (Tg) leve...

Aim: Several studies suggested that there is a relationship between serum levels of IGF1 or their polymorhisms and some cancer types. The genetic polymorphism in the region of IGF promoter region which is composed of cytosine–adenine repeats, affects the promoter activity. It is suggested that serum IGF1 levels are inversely associated with the length of CA repeats. There are studies reporting that the carriers of the CA 19 allele are more likely to develop some cancer ty...

Less than 1% cases of acromegaly is caused by ectopic secretion of growth hormone releasing hormone (GHRH).A 25-year-old woman was admitted to the hospital, with iron deficiency anemia, acromegaly and a 6×6 cm mass in infrahepatic location near to the pancreatic head. Sellar magnetic resonance (MR) imaging indicated pituitary enlargement without obvious evidence of a pituitary adenoma. The patients underwent abdominal exploration. Histopathological ...

Introduction: Fibroblast growth factor (FGF)-23 is a peptid, released from bone tissue and osteogenic cells. Phosphatonins regulate phosphate homeostasis in some phosphate wasting disorders such as X-linked hypophosphatemia, otozomal dominant hypophosphatemic rickets, and tumor-induced osteomalacia.FGF-23 is a possible phosphatonin: it regulates phosphate homeostasis by PTH independent actions.Objective: In the present study, we ai...

Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by decreased responsiveness of target tissues to thyroid hormone. Two members of a Turkish family, a mother and son, had thyroid function tests suggestive of resistance to thyroid hormone (RTH).Methods: The clinical presentation was, however, different. The mother (proposita) had palpitation, weakness, tiredness, nervousness, dry mouth and was misdiagnosed as...

Introduction: We report a case of paraganglioma of glomus caroticum with lung metastases treated with 150 mCi 131I-MIBG.Case: A 25-year-old woman was referred to our department for cachexia. She had low BMI (18) normotension, mild normochromic normocytic anemia with a mass under left mandibula. Radiologic imaging of neck revealed that 24×36×45 mm diameter mass surrounding of carotis externa and interna at the level of bifurcation. She underwent...

Introduction: We designed a retrospective study to investigate the clinical presentation, laboratory and pathological findings of 14 patients with ACTH-independent macronodular adrenal hyperplasia.Materials and methods: Diagnose of Cushing’ s syndrome was confirmed by biochemical tests, adrenal hyperplasia was confirmed by pathological examination in all patients.Results: No supression was observed in overnight, low and high d...

Introduction: Isolated bone metastasis of endometrium carcinoma is rare; but if it occurs, pelvis and vertebrae are involved mostly. Co-existence of undiagnosed Paget’s disease in a patient with malignancy causes major problems in differential diagnosis.Case: A 77 year-old woman was admitted to our hospital with severe pelvic pain. She had been diagnosed with inoperable endometrium adenocarcinoma for over a year. Metastatic bone disease was suspecte...

Aim: Thyroid hormones play an important role in bone remodeling. The aim of the study was to evaluate the changes of bone markers and osteoprotegerin (OPG)/sRANK-L levels during follow-up in a group of patients with thyroid cancer.Material and methods: Twenty euthyroid women with the diagnosis of differentiated thyroid cancer were enrolled to the study (39.25±13.46 years, 6 postmenopausal) before thyroidectomy. Samples were collected before the oper...

The aim of this study is to evaluate endothelial function in patients with primary hyperparathyroidism (pHT) during the preoperative hypercalcemic and postoperative normocalcemic periods and to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function. Forty-one patients with pHT (28 women, 12 men; age: 48.4±11.6 years, serum calcium: 11.4±1.0 mg/dl, parathyroid hormone: 373.3±394.5 pg/ml) who fulfilled the criteria for parathyroid ...